Phytochemical and Network Pharmacology Based Evaluation of Antiepileptic Potential of Identified Metabolites in Argimone mexicana

Pharmacognosy Research,2021,13,4,208-217.DOI:10.5530/pres.13.4.13Published:October 2021Type:Original ArticleAuthors:Vinod Gahlot, and Dinesh Kumar Yadav Author(s) affiliations:Vinod Gahlot1, Yadav2,* 1Department of Pharmacology, SGT College Pharmacy, University, Gurugram, Haryana, INDIA. 2Department Pharmacognosy, Abstract:Background: Quality-based assessment herbal drugs or products is being more concerning for their quality, safety regulatory purpose. A. mexicana a traditional medicine that has long history in the treatment arthritis, anti-fungal anti-cancer brain disorders. Aim: Due to lack scientific evidence based on phytopharmacology, study aimed phytochemical antiepileptic evaluation identified metabolites mexicana. Materials Methods: Phytochemical identification was done using MS, FTIR 1H-NMR quantitated HPTLC densitometric analysis. Further, ADME network pharmacology studies were performed evaluate biological response metabolites. Results: The resulted outcomes spectral analysis suggest isolated compounds as ferulic acid, caffeic berberine angoline. In quantitative analysis, content angoline found 3.475 ± 0.028, 1.036 0.013, 0.714 0.014 0.738 0.081 μg/mg extract. showed good bioavailable while except angoline, all significantly interacted with several genes (SOD1, NOS, MAPK3, UGT1As, G6PD, ACOT2, BAAT etc) associated ischemia, oxidative inflammatory stress elimination toxins from body. Conclusion: Hence, enlightens possess major minor which can be key parameter further quality Mexicana role against induced epileptic seizure. Keywords:ADME Argemone L., HPTLC, Network pharmacology, PhytoconstituentsView:PDF (1.81 MB)